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发表于 2008-1-1 20:25:03
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http://www.usdoj.gov/dea/concern/mdma/mdmaindex.htm
MDMA (ECSTASY)
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MDMA (ECSTASY)
MDMA (3, 4-Methylenedioxymethamphetamine) is a Schedule I synthetic, psychoactive drug possessing stimulant and hallucinogenic properties. MDMA possesses chemical variations of the stimulant amphetamine or methamphetamine and a hallucinogen, most often mescaline. Commonly referred to as Ecstasy or XTC, MDMA was first synthesized in 1912 by a German company possibly to be used as an appetite suppressant. Chemically, it is an analogue of MDA, a drug that was popular in the 1960s. In the late 1970s, MDMA was used to facilitate psychotherapy by a small group of therapists in the United States. Illicit use of the drug did not become popular until the late 1980s and early 1990s. MDMA is frequently used in combination with other drugs. However, it is rarely consumed with alcohol, as alcohol is believed to diminish its effects. It is most often distributed at late-night parties called "raves," nightclubs, and rock concerts. As the rave and club scene expands to metropolitan and suburban areas across the country, MDMA use and distribution are increasing as well.
MDMA is taken orally, usually in tablet or capsule form, and its effects last approximately four to six hours. Users of the drug say that it produces profoundly positive feelings, empathy for others, elimination of anxiety, and extreme relaxation. MDMA is also said to suppress the need to eat, drink, or sleep, enabling users to endure two- to three-day parties. Consequently, MDMA use sometimes results in severe dehydration or exhaustion. While it is not as addictive as heroin or cocaine, MDMA can cause other adverse effects including nausea, hallucinations, chills, sweating, increases in body temperature, tremors, involuntary teeth clenching, muscle cramping, and blurred vision. MDMA users also report after-effects of anxiety, paranoia, and depression. An MDMA overdose is characterized by high blood pressure, faintness, panic attacks, and, in more severe cases, loss of consciousness, seizures, and a drastic rise in body temperature. MDMA overdoses can be fatal, as they may result in heart failure or extreme heat stroke.
The effects of long-term MDMA use are just beginning to undergo scientific analysis. In 1998, the National Institute of Mental Health conducted a study of a small group of habitual MDMA users who were abstaining from use. The study revealed that the abstinent users suffered damage to the neurons in the brain that transmit serotonin, an important biochemical involved in a variety of critical functions including learning, sleep, and integration of emotion. The results of the study indicate that recreational MDMA users may be at risk of developing permanent brain damage that may manifest itself in depression, anxiety, memory loss, and other neuropsychotic disorders.
Clandestine laboratories operating throughout Western Europe, primarily the Netherlands and Belgium, manufacture significant quantities of the drug in tablet, capsule, or powder form. Although the vast majority of MDMA consumed domestically is produced in Europe, a limited number of MDMA labs operate in the United States. In addition, in recent years, Israeli organized crime syndicates, some composed of Russian emigres associated with Russian organized crime syndicates, have forged relationships with Western European traffickers and gained control over a significant share of the European market. The Israeli syndicates are currently the primary source to U.S. distribution groups.
Overseas MDMA trafficking organizations smuggle the drug in shipments of 10,000 or more tablets via express mail services, couriers aboard commercial airline flights, or, more recently, through air freight shipments from several major European cities to cities in the United States. The drug is sold in bulk quantity at the mid-wholesale level in the United States for approximately eight dollars per dosage unit. The retail price of MDMA sold in clubs in the United States remains steady at twenty to thirty dollars per dosage unit. MDMA traffickers consistently use brand names and logos as marketing tools and to distinguish their product from that of competitors. The logos are produced to coincide with holidays or special events. Among the more popular logos are butterflies, lightning bolts, and four-leaf clovers.
While MDMA abuse currently is not as widespread as that of many other drugs, it nonetheless increased significantly--500 percent--over a five-year period. Drug Abuse Warning Network (DAWN) estimates reveal that nationwide hospital emergency room mentions for MDMA rose dramatically from 70 in 1993 to 2,850 in 1999. Seizures of MDMA have also increased drastically. Over a six-year period, seizures of MDMA tablets submitted to DEA laboratories have risen from a total of 196 in 1993 to 143,600 in 1998. Seizures from January through May 1999 total over 216,300 MDMA tablets; the 1999 figure will most likely double the 1998 figure.
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"ECSTASY" DAMAGES THE BRAIN AND IMPAIRS MEMORY IN HUMANS
By Robert Mathias
NIDA NOTES Staff Writer
ANIDA-supported study has provided the first direct evidence that chronic use of MDMA, popularly known as "ecstasy," causes brain damage in people. Using advanced brain imaging techniques, the study found that MDMA harms neurons that release serotonin, a brain chemical thought to play an important role in regulating memory and other functions. In a related study, researchers found that heavy MDMA users have memory problems that persist for at least two weeks after they have stopped using the drug. Both studies suggest that the extent of damage is directly correlated with the amount of MDMA use.
"The message from these studies is that MDMA does change the brain and it looks like there are functional consequences to these changes," says Dr. Joseph Frascella of NIDA's Division of Treatment Research and Development. That message is particularly significant for young people who participate in large, all-night dance parties known as "raves," which are popular in many cities around the Nation. NIDA's epidemiologic studies indicate that MDMA (3,4-methylenedioxymethamphetamine) use has escalated in recent years among college students and young adults who attend these social gatherings.
In the brain imaging study, researchers used positron emission tomography (PET) to take brain scans of 14 MDMA users who had not used any psychoactive drug, including MDMA, for at least three weeks. Brain images also were taken of 15 people who had never used MDMA. Both groups were similar in age and level of education and had comparable numbers of men and women.
In people who had used MDMA, the PET images showed significant reductions in the number of serotonin transporters, the sites on neuron surfaces that reabsorb serotonin from the space between cells after it has completed its work. The lasting reduction of serotonin transporters occurred throughout the brain, and people who had used MDMA more often lost more serotonin transporters than those who had used the drug less.
Previous PET studies with baboons also produced images indicating MDMA had induced long-term reductions in the number of serotonin transporters. Examinations of brain tissue from the animals provided further confirmation that the decrease in serotonin transporters seen in the PET images corresponded to actual loss of serotonin nerve endings containing transporters in the baboons' brains. "Based on what we found with our animal studies, we maintain that the changes revealed by PET imaging are probably related to damage of serotonin nerve endings in humans who had used MDMA," says Dr. George Ricaurte of The Johns Hopkins Medical Institutions in Baltimore. Dr. Ricaurte is the principal investigator for both studies, which are part of a clinical research project that is assessing the long-term effects of MDMA.
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